Oncotarget is a journal covering researches involving oncology, a branch of science which deals with all aspects of cancer from its treatment to prevention, and cure. Oncotarget conducts analyses on every scientific archive to make reliable results rapidly to be accessed by other medical specialists. The bio-medical journal avails its publications to the people through the PubMed Central, PubMed, Embase, BIOSIS, and Scopus. From the 19th of September 2017, the journal intends to publish two publications each week on Tuesday and Friday to avail oncologists the latest researches on cancer.
On a recent publication from Oncotarget on the 20th of November 2017, the journal published the new research as to how cancer cells move to all parts of the body. Cells from the initial tumor become metastatic and spread from that part of the body to another leading to formation of a secondary tumor. The process that allows the cells to move is the epithelial-to-mesenchymal transition (EMT) process. EMT process is activated by the proteins called transforming growth factor β (TGFβ). The protein also activates the SNAI1 protein which is also responsible for the EMT process. Learn more about Oncotarget at Research Gate.
Researchers are currently focusing on the EMT process which causes cancer cells to become metastatic which will inhibit the spread of cancer cells to other parts of the body. Oncotarget released research conducted by the Uppsala and Umea University which can help in altering of the SNAI1 protein. The process involves altering one amino-acid making up the protein. The process is also referred to as sumoylation. The amino-acid making the Snaill protein alteration causes the protein itself to have a remodeled structure as well as the metastatic and invasive properties of cancer cells.
The research teams also discovered that the SNAI1 protein was responsible for expressing oncogenes thus the best method to inhibit the expression is by affecting the very SNAI1 protein. So far, the team has made the research to inhibit prostate cancer cells and is now focusing on breast cancer tumors. The plan for the future is to be able to inhibit the expression of different cancer cells within major organs of the body and to be able to stop cancer disease in the body. Watch this video on Youtube.